Rodriguez started Game 2 of Saturday's 2-1 doubleheader loss to San Francisco, allowing no runs on one hit and three walks with two strikeouts in four innings. He received a no-decision.

Making his first start of 2021 and his first appearance since 2019, Rodriguez engaged in an abbreviated pitcher's duel with the Giants' bullpen. The successful outing may have earned Rodriguez another start with Stephen Strasburg still injured despite Rodriguez being the 27th man for Saturday's doubleheader.