Despaigne was optioned to Triple-A Norfolk on Saturday.
Despaigne was recalled to Baltimore earlier in the day and pitched three innings (four runs, five hits, two walks) in a 12-2 loss to the Astros after starter Chris Tillman was bounced early. The O's have allowed 27 runs over the past two games and burned many relievers in the process, which is why Despaigne was called up in the first place. Having thrown 71 pitches Saturday, he will not be available for Baltimore on Sunday, so they will get another bullpen arm for the series finale Sunday.