Lyles will start Friday against the Diamondbacks.
The Padres are planning to deploy a six-man rotation the rest of the way, with Lyles following Clayton Richard in the series opener in Arizona. Lyles held the Dodgers to two runs over 4.1 innings in his first start of the season last week, but he had more walks (4) than strikeouts (3). Further, he gave up 11 homers in 46.2 innings with the Rockies earlier this year, so it could get ugly in a hurry against the Diamondbacks.