Ruf is in the lineup Wednesday versus the Reds, batting fifth and playing first base.
The 29-year-old ceded the start on Opening Day to Ryan Howard with righty Raisel Iglesias on the mound, but Ruf will garner the start Wednesday with the left-handed Brandon Finnegan going for Cincinnati. He dominated left-handed pitching last season, posting a 1.107 OPS against them in the 2015 campaign, so he'll look to continue that trend this season as he platoons with Howard at first base.