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Skenes didn't factor into the decision in Thursday's Opening Day game against the Marlins. He allowed two runs on three hits and two walks while striking out seven across 5.1 innings.

Skenes picked up where he left off from his 2024 NL Rookie of the Year campaign by striking out four of the first six batters he faced Thursday. He gave up single tallies in the third and sixth frames, the latter of which came on a passed ball after being replaced by Dennis Santana. Skenes was further let down by the bullpen in the eighth and ninth innings, costing him the win. A matchup with the Rays likely awaits next week for the right-hander.

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