Palacios went 1-for-2 with a three-run home run and a strikeout during the Rays' 11-3 win over the Guardians on Friday.
Palacios took over at second base for Ryan Vilade in the seventh inning. The 29-year-old made a huge impact in his second at-bat with a long three-run homer to give the Rays an 11-1 lead. After picking up his first long ball since July 10, Palacios is now slashing .233/.328/.344 with four homers, 30 RBI and nine stolen bases in 247 plate appearances this season.