Yoshida left Saturday's game early in the top of the third inning against the Pirates after sliding into second base on a double, Gabrielle Starr of the Boston Herald reports.
The 33-year-old slid headfirst into second base after legging out a double and came up limping before being removed from the game in the third inning, exiting with left hamstring tightness, per Ian Browne of MLB.com. Anthony Seigler pinch-ran for Yoshida at second base and will remain in the game as Boston's designated hitter. If Yoshida is to miss time, Romy Gonzalez would be a potential replacement after logging a four-hit game Saturday with Triple-A Worcester.