Spiers is likely to enter the Reds' rotation in place of the injured Julian Aguiar (shoulder), Charlie Goldsmith of The Cincinnati Enquirer reports.
Aguiar had been slated to make his final start of the season Wednesday in Cleveland, but that assignment should fall to Spiers, who will be on seven days' rest after throwing 46 pitches over three relief innings last week against Atlanta. It will be Spiers' first start since Aug. 20, when he allowed 10 runs (nine earned) across 4.1 frames in Toronto.