Mesoraco is batting seventh and catching Friday against the Cardinals.
It will be a long-awaited debut for Mesoraco, who last played in a major-league game on April 27 of last year. The 28-year-old backstop will likely be eased into the everyday catcher role ahead of Tucker Barnhart, but will need to show consistency at the plate after hitting just .170 in 13 rehab games for Double-A Pensacola.