Mesoraco is not in the lineup for Wednesday's game against the Rockies, according to MLB.com's Jamie Ramsey.
Mesoraco will be held out of the lineup Wednesday for the second time in three games, but he remains the Reds' primary catcher, and is likely just getting the day off with the Reds playing a day game following a night game. Tucker Barnhart will get the start behind the plate in Mesoraco's place.