Smith started at first base and went 0-for-3 in Thursday's 7-0 loss to the Pirates.
Smith, who was signed earlier in the day after being released by Boston on Tuesday, made his debut for the Reds. With Jeimer Candelario (toe) and Jake Fraley (knee) landing on the the 10-day injured list in recent days, the Reds could have regular spots in the lineup available for both Smith and Ty France against right-handed pitching at either first base and designated hitter.