Lowe is out of the lineup for Wednesday's game against the Guardians.
After going 5-for-12 with a double, two RBI and a run scored while starting in the Reds' last three games, the left-handed-hitting Lowe will head to the bench while the Guardians send southpaw Joey Cantillo to the bump. Sal Stewart will move across the diamond to replace Lowe at first base while Ke'Bryan Hayes picks up a start at third base.