Reds starter Anthony DeSclafani (1-0) held the Cubs to just two hits and no runs in seven innings on Tuesday to record the win.
DeSclafani struck out five in the victory.
Reds manager Bryan Price was impressed with the DeSclafani's performance.
'"Very much so, because here's a rookie coming in with this team on a three-game skid where let some leads get away," Price said.
DeSclafani's next start is scheduled for Monday in Milwaukee.