Lyles, who is competing for a rotation spot this spring, will start Thursday's Cactus League game against Arizona, the Rockies' official site reports.
After missing most of 2015 with a toe injury that required surgery, Lyles enters camp with a career 5.10 ERA in 104 big league appearances (552.2 innings), and he can no longer be optioned to the minors without getting exposed to waivers. If he's unable to stick as a starter this spring, the Rockies may elect to hold onto him in middle relief as he's still just 25 years old.