The Royals designated Cerantola for assignment Thursday.
After being sent down to Triple-A on Wednesday, Cerantola will now give up his place on the 40-man roster for Luke Maile, who was selected to the big leagues in a corresponding move. Cerantola walked six batters while giving up two runs in 1.1 innings during his appearance against the Rays on Tuesday, and he'll likely need to show improvement at Omaha before the Royals consider giving him another opportunity in the majors.