Lorenzen was removed from Tuesday's game against the Guardians due to a left hamstring strain.
Lorenzen suffered the injury covering first base while attempting to complete a double play in the second frame. He was initially able to remain in the game to face another batter but was relieved before he could finish the inning. The 32-year-old is currently scheduled to start again in Houston over the weekend, though there is a chance he'll need to spend time on the injured list.