Castillo was optioned to Triple-A Toledo on Thursday.
Castillo will head back to the minors after being called up Sunday and delivering 1.2 scoreless innings Monday against the Angels. The 27-year-old righty has been dominant at Triple-A Toledo this season with a 1.79 ERA and 1.20 WHIP and has 38 strikeouts over 40.1 innings out of the bullpen.