Manning was optioned to Triple-A Toledo after Detroit's 9-1 loss to Toronto on Thursday.
The 26-year-old righty will head back down to Toledo with Kenta Maeda being reinstated from the 15-day injured list. Manning has started five games for the Tigers this season, recording a 4.88 ERA and 1.55 WHIP with a 23:12 K:BB across 27.2 innings.