Santiago (shoulder) tossed three scoreless innings in a minor-league rehab start for Triple-A Rochester on Wednesday, MLB.com reports. He struck out two and walked two.
Santiago's velocity was where it should be and he was able to use all of his pitches, so it's possible his next start will be with the big club if everything checks out. He's expected to fly with the team to Cleveland on Friday, at which point a decision will be made about his next step. The 29-year-old owns a 5.26 ERA and 47:28 K:BB through 65 innings this season (13 appearances, 12 starts).