Santiago (10-7) allowed seven runs on nine hits while striking out two over four innings to take the loss Sunday against the Royals.
Santiago has struggled mightily since joining the Twins, as he's allowed 15 earned runs in 14.1 innings over three starts to raise his ERA from 4.25 to 4.80 on the year. He currently owns the highest ERA of any season in his six-year career. He'll make his next start Saturday against the Royals.