Santiago (4-5) was tagged for six runs on eight hits, including three home runs, and gave up two walks over six innings in Wednesday's 17-6 loss to the Astros. He struck out three.
Houston ended up pounding out six homers on the day, but the Twins very nearly got Santiago off the hook for the loss by narrowing the gap to 6-5 in the bottom of the sixth inning before their bullpen imploded. The left-hander has now served up a brutal 10 homers in his last 20 innings, sending his ERA skyrocketing to 4.76 -- a full two runs more than his mark when his struggles keeping the ball in the park began. He'll try to figure things out in his next start Tuesday in Seattle.