Santiago (4-1) allowed two runs on three hits and five walks while striking out six over 6.2 innings in Tuesday's 7-2 win over the White Sox.
The left-hander has now walked 12 batters in his last 17.2 innings, a worrying sign, but so far he's been able to escape any serious damage. Santiago will next take the mound Sunday in Cleveland against an Indians squad that sits 25th in wOBA (.286) against southpaws.