Odorizzi (5-10) took the loss Wednesday, allowing five runs on four hits and four walks while striking out four over 4.2 innings against the Astros.
Odorizzi was tagged for a pair of two-run home runs and didn't have great control, with four walks and a hit by pitch. The 28-year-old has taken the loss in three consecutive outings and now sees his ERA sit at 4.57. He'll also carry a 1.36 WHIP and 148:61 K:BB across 147.2 innings into another tough matchup Wednesday against the Yankees.