Ryan was removed from Wednesday's start against the Cubs in the bottom of the third inning with an undisclosed injury, Dan Hayes of The Athletic reports.

Ryan called for the trainer after delivering a pitch to Pete Crow-Armstrong, who was leading off the third inning for the Cubs. After a brief conversation with the trainer and manager Rocco Baldelli, Ryan exited without throwing a warmup pitch. He allowed one run on one hit over two-plus frames before being lifted.