Diamondbacks starter Wade Miley endured a rough outing as he suffered his sixth loss of the season Saturday night against the Padres.

Miley (4-6) pitched three perfect innings to start the game before surrendering five runs in the fourth, including a three-run home run to Yasmani Grandal. The left-hander permitted six runs -- one earned -- on six hits and one walk while striking out four in six innings pitched in a 6-4 loss.

Miley has lost five of his lasts even starts. He has seen his ERA rise from 2.93 to 4.64 over that span. He is scheduled to make his next start Friday at home against the Reds. He is 1-2 with a 6.86 ERA in four starts away from home.