White Sox starter Jose Quintana (1-2) gave up one run on six hits in seven innings on Friday but received no run supoort and took the hard-luck loss against the Twins.
The lone scored by the Twins was via a wild pitch.
Quintana fanned five and walked two in the loss.
"He was sharp, he got into a couple binds and he battled through it," White Sox manager Robin Ventura said. "The [wild pitch] is just one of those you'd like to have back."
Quintana's next start is scheduled for Thursdsay against the Tigers.