The White Sox selected Colome's contract from Triple-A Charlotte on Tuesday.
Colome held a 2.25 ERA and 7:4 K:BB over eight innings with Charlotte to earn another shot in the majors. The 34-year-old reliever posted a 2.27 ERA over 83 appearances for the White Sox from 2019-20 but has struggled mightily at the big-league level since then.