The White Sox placed Baldwin on the 10-day injured list Wednesday with a right wrist sprain, LaMond Pope of the Chicago Tribune reports.
A hand injury kept Baldwin sidelined for seven consecutive games before he entered Tuesday's game off the bench, though he'll now need to miss at least another 10 days after injuring his wrist. Lenyn Sosa will presumably continue to see regular starts while Baldwin is out, and Bryan Ramos will come up from Triple-A Charlotte to replenish Chicago's infield depth.