Murphy will serve as the White Sox's opener for Sunday's game against the Guardians, Scott Merkin of MLB.com reports.
Murphy will make his second start of the season but is expected to work just one or two innings before bulk reliever Erick Fedde takes over. Through 18 appearances with Chicago, Murphy has compiled a 3.79 ERA, 1.37 WHIP and 18:10 K:BB across 19 innings.