The White Sox placed Murphy on the 15-day injured list Thursday, retroactive to Wednesday, with a left elbow impingement.
Murphy gave up one earned run on a solo homer in two-thirds of an inning during his last appearance Tuesday, and he appears to have come away from his latest outing with a nerve issue in his elbow. He'll be sidelined for at least the next two weeks as a result, and with Tyler Schweitzer on his way back to Triple-A, the White Sox will bring Duncan Davitt and Brandon Eisert up from Charlotte to fill the holes on their pitching staff.