Lopez is out of the lineup for Wednesday's game against the Guardians.
With lefty Matthew Boyd on the bump for the Guardians, the lefty-hitting Lopez will give way to Jacob Amaya at shortstop. Lopez had started in five of the White Sox's six matchups with right-handed pitchers in September, so he should maintain a strong-side platoon role in the middle infield, at least until Brooks Baldwin (wrist) comes off the injured list.