George has been ruled out for Wednesday's game against the Cavaliers due to left knee injury management, Shams Charania of ESPN reports.
George and Joel Embiid (knee) will both rest for the second half of Philadelphia's back-to-back set, opening up plenty of minutes for several other player. In Tuesday's 111-99 loss to the Knicks, George had his best game of the season, posting 29 points (10-19 FG, 7-11 3Pt, 2-2 FT), 10 rebounds, three assists, three steals and one block in 32 minutes. George should return to action Friday in Orlando.