Simons is listed as questionable for Friday's game against the Rockets with a right hand sprain.
Simons had missed Portland's last three games with an illness, but it's a new issue that's threatening his availability for the front end of a back-to-back set in Houston. If the 25-year-old is unable to make his return to game action Friday, Dalano Banton will likely receive an increased role with Scoot Henderson (quadricep) also deemed questionable.