Hopkins (illness) is listed as questionable for Sunday's game against the Titans after not practicing Friday, Aaron Wilson of the Houston Chronicle reports.
Though coach Bill O'Brien has indicated that the Texans plan to play to win Sunday's contest, Houston would be unable to change its playoff seed if the Chiefs beat the Chargers. Considering Kansas City kicks off at 1 p.m. ET and the Texans don't play until 4:25 p.m. ET, O'Brien could choose to rest or limit key players like Hopkins, even if they aren't included among the team's inactives.