Aiyuk (hamstring) practiced fully Wednesday, Keiana Martin of the 49ers' official site reports.
Aiyuk was limited to just one appearance during exhibition season, gathering in one of three passes for three yards Aug. 22 versus the Chargers. Thereafter, a hamstring injury has been bothering him, but it's apparently dissipated enough for him to partake in all drills in the first practice of Week 1. Aiyuk will pair with Deebo Samuel to serve as the top two wide receivers in San Francisco's offense in the coming campaign.