San Francisco head coach Kyle Shanahan said that he doesn't expect Aiyuk (hamstring) to practice Wednesday, David Lombardi of The Athletic reports.
The 49ers' first official injury report of the season will be released later Wednesday, revealing whether or not Aiyuk was actually able to put any work in. Even if he's listed as a non-participant Wednesday as expected, the rookie first-round pick would still have a shot at playing in Sunday's season opener against the Cardinals with limited activity in session Thursday or Friday.