49ers' Christian McCaffrey: Headed to IR, out at least six weeks

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Head coach Kyle Shanahan said Monday that McCaffrey is headed to injured reserve and is expected to need at least six weeks to recover from the PCL injury he suffered in Sunday's 35-10 loss to the Bills, Ian Rapoport of NFL Network reports.

McCaffrey sustained the injury in the first half of Sunday's contest, when his right knee appeared to give out on him when he attempted to run upfield on a pitch to the outside. Jordan Mason stepped in for McCaffrey and took on the majority of the snaps out of the backfield, but he too is bound for IR after suffering a high-ankle sprain late in the contest. With the top two backs on the 49ers' roster out until at least Week 18, rookie Isaac Guerendo vaults to the top spot on the depth chart and could be in line for a three-down role, making him a priority pickup in all fantasy leagues where he's available. McCaffrey, meanwhile, could have an outside chance at making it back in action if the 49ers make a deep playoff run, though their postseason hopes are fading as they head into Week 14 with a 5-7 record. Shanahan said that McCaffrey won't require surgery on the knee injury, so the star tailback should be back to full health in advance of OTAs in the spring.