Head coach Kyle Shanahan said McCaffrey will be a limited participant at Wednesday's practice, but the running back has exhibited "no pain" in either of his Achilles, Adam Schefter of ESPN reports.
The 49ers designated McCaffrey for return from injured reserve Monday following their Week 9 bye, opening a 21-day window in which to evaluate him for a return to the active roster. The team has been circling this Sunday's game at Tampa Bay as his likely season debut, but McCaffrey may need to conclude this week with a full practice in order to go into the weekend without a designation.