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The 49ers may place McCaffrey (calf/Achilles) on injured reserve Saturday, Ian Rapoport of NFL Network reports.

In order to start McCaffrey's four-game tally, at the very least, on IR, San Francisco can take that approach before Saturday's 4:00 p.m. ET deadline for such a transaction. He initially dealt with a calf strain throughout training camp and the preseason, but his situation was thrown into no-man's land when Achilles was attached to his name on the team's first Week 1 injury report last Thursday. There was no indication outside the 49ers' organization that McCaffrey was in danger of sitting out this past Monday against the Jets until inactives dropped before the game, and since then it was revealed he was tending to Achilles tendinitis, which requires rest to get past completely. With Jordan Mason faring well in McCaffrey's absence, the team seems poised to roll with the former out of the backfield in the short term, with the aim to get its star RB healthy with the second half of the season and playoffs in mind.

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