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McCaffrey has been ruled out for Sunday's game at Minnesota, and the 49ers are considering placing him on injured reserve, which would sideline him through at least Week 5, Tom Pelissero of NFL Network reports.

Jordan Mason enjoyed a breakout performance Week 1 against the Jets, taking 29 touches for 152 yards and a touchdown on 81 percent snap share, with wide receiver Deebo Samuel also picking up some of the backfield slack and tying his career high of eight carries. It sounds like that scenario could continue for several weeks, as coach Kyle Shanahan told reporters Friday that Thursday was McCaffrey's worst day so far in terms of pain, per Nick Wagoner of ESPN.com. It's been a rapid downward slide for McCaffrey and his fantasy managers, after most reports last week suggested he was on track to play in the season opener. He'll now miss a second straight game, at the very least.

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