Samuel (glute) is expected to play in Sunday's preseason game at the Chargers, Eric Branch of the San Francisco Chronicle reports.
There was some question about whether Samuel would be able to suit up just two days removed from exiting Friday's joint practice with the Chargers due to a "tight glute." But he'll buck the odds and likely be available for Jimmy Garoppolo and Trey Lance alongside fellow wide receivers Brandon Aiyuk and Mohamed Sanu.