Samuel (calf) won't practice Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
With Christian McCaffrey (calf/Achilles) out Weeks 1 and 2, Samuel was getting some run out of the 49ers backfield in addition to his work as a receiver. Overall, Samuel had 23 touches for 177 yards from scrimmage and one rushing touchdown before he strained his right calf in the waning moments of this past Sunday's loss in Minnesota. Coach Kyle Shanahan relayed Monday that Samuel is in line for a multi-game absence, and George Kittle (hamstring) joined him on the injury report Thursday as a non-participant, leaving San Francisco potentially down three of its top skill-position talents Week 3. Currently, WR Brandon Aiyuk is the lone healthy regular, while Jauan Jennings, Chris Conley, Ronnie Bell and Jacob Cowing are the other options at the position on the active roster.