The 49ers designated Samuel (foot) to return from injured reserve Wednesday.
The transaction opens up a 21-day practice window through which the 49ers will be able to evaluate Samuel for a return to the active roster. San Francisco could technically activate Samuel in time for him to suit up Sunday versus the Eagles, but the team is believed to be targeting its Week 5 game against the Dolphins for the wideout's 2020 debut. Kendrick Bourne and Brandon Aiyuk will continue to serve as the team's top wideouts until Samuel is able to return, with Trent Taylor, Mohamed Sanu and Dante Pettis all handling depth roles.