Samuel (hamstring) won't return to Sunday's game versus Washington, Matt Maiocco of NBC Sports Bay Area reports.
Samuel injured his hamstring on the first play from scrimmage, a nine-yard run by the second-year wide receiver. With the decision made to keep Samuel out for the rest of the contest, the 49ers are down to Brandon Aiyuk, Kendrick Bourne, Richie James and River Cracraft as healthy options at wide receiver.