Head coach Kyle Shanahan said Samuel won't practice Wednesday due to a calf injury, Nick Wagoner of ESPN.com reports.
Per Cam Inman of The San Jose Mercury News, Shanahan noted Samuel looked "OK" during Wednesday's walk-through, while relaying optimism that the wide receiver will be available for Sunday's game at Chicago. Samuel still has a pair of practices this week to get back on the field and prove the health of his calf, but his status now bears watching as the weekend approaches.