Samuel caught eight of 11 targets for 112 yards in Monday night's 27-24 overtime loss to the Seahawks.
Samuel's career-best outing saw him pick up the slack after fellow wideout Emmanuel Sanders was forced to exit due to a rib injury. With Pro Bowl tight end George Kittle (knee/ankle) sidelined as well, Samuel led San Francisco in all major receiving categories, adding a game-long gain of 30 yards for good measure. The rookie second-rounder would figure to remain a focal point should Sanders and Kittle remain out in Week 11 versus the Cardinals, but their availability will need to be tracked in advance of kickoff in order to form a clearer outlook.