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Flannigan-Fowles (calf) has been ruled out ahead of Thursday night's matchup against the Seahawks, Eric Branch of the San Francisco Chronicle reports.
The 28-year-old linebacker is now in line to miss his second consecutive game due to a calf injury. While Flannigan-Fowles remains sidelined, expect Dee Winters to see increased work with San Francisco's first-team defense.
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