Kittle will be held out of Wednesday's practice with knee soreness, Nick Wagoner of ESPN.com reports.
Kittle is banged up following five straight games with 50-plus snaps and consecutive contests with double-digit targets. The initial report suggests Kittle's knee is merely sore, but it's unclear if he'll be able to get back on the practice field Thursday or Friday as the Niners prepare for Sunday's home game against Atlanta.