Kittle (hamstring), who is listed as questionable for Sunday's game against Seattle, is unlikely to play, Adam Schefter of ESPN reports.
The 49ers will see how he feels pregame, but at this stage, the team isn't optimistic that Kittle will be able to play still be a chance he can play. Official word on Kittle's status will arrive 90 minutes prior to the 4:05 p.m. ET kickoff, when the 49ers release their inactive list. After handling a normal snap count in the 49ers' Week 10 win over the Buccaneers, Kittle sat out Wednesday's practice with the hamstring injury, then was a limited practice participant Thursday and Friday. Eric Saubert would likely start at tight end if Kittle is inactive, but he would serve primarily as a blocker and wouldn't be nearly as involved as Kittle in the passing game.