Kittle isn't expected to play in Friday's preseason game against the Packers, Nick Wagoner of ESPN.com reports.
Kittle will be among a number of 49ers regulars sitting out their exhibition opener, including running back Elijah Mitchell (hamstring) and wide receivers Deebo Samuel and Brandon Aiyuk. Tyler Kroft, Ross Dwelley, Tanner Hudson and Troy Fumagalli represent the team's healthy and available tight ends Friday.